张西亚_河南农业大学机电工程学院

姓名	张西亚	导师类别	博导
出生年月	1987.04	E-mail	zhangixya@henau.edu,.cn
职称/职务	副教授	学历/学位	博士学位
讲授课程	《仪器分析》、《食品安全案例分析》、《食品安全与检测研究进展》
指导研究生学科	食品科学与工程
研究方向	食品安全快速检测方向
承担教学、科研项目情况	1. 国家基金面上项目，32472436，果蔬中蛋白、脂肪及金属离子产生侧流层析免疫分析基质效应的机制及消除研究，2025/1-2028/12，在研，主持。 2. 国家基金面上项目，32172298，半抗原中苯环间隔臂连接位点制备抗原对抗体灵敏度影响机制研究，2022/1-2025/12，在研，主持。 3. 国家青年基金项目，31802249，“turn-on”型荧光能量共振转移侧流层析猝灭效率机制研究及体系的构建，2019/1-2021/12，结项，主持。 4. 河南省高校科技创新人才，25HASTIT044，抗体定向标记减弱果蔬中干扰蛋白产生免疫层析基质效应的研究，2025/1-2027/12，在研，主持。 5. 河南省优秀青年项目，252300421161，低共熔溶剂减弱高脂肪样本产生的侧流层析基质干扰机制及应用研究，2025/1-2027/12，在研，主持。 6. 河南科技攻关项目，222102310162，均一识别性泰乐菌素/替米考星抗体的分子识别机制及应用研究，2022/1-2023/12，结项，主持。 7. 河南省高等学校重点科研项目，20A550009，样品富集净化与可视化检测一体化新型免疫分析方法研究，2019/12-2021/12，结项，主持。 8. 河南省高等学校大学生创新训练计划项目，201910466023，苯环邻位、间位和对位作为间隔臂连接位点对小分子化合物特异性抗体产生的影响机制研究，2019/5-2021/4，项目指导老师，结项。 9．河南农业大学拔尖人才项目，30501305，2022/10-2027/9，在研，主持。
论著、论文、专利等情况	进三年发表论文情况： 1. Tong Bu, Changwei Luo, Mengzhuo Fan, Yu Wang, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Xiya Zhang. Advances in bioluminescence resonance energy transfer systems: Donor-acceptor design, transfer efficiency improvement, and applications. Coordination Chemistry Reviews, 2025, 543, 216937. 2. Changwei Luo, Mengzhuo Fan, Mengtian Chen, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Tong Bu, and Xiya Zhang. Engineered CeO2@Ru Nanospheres via Size-Metal-Loading Synergy to Enhance Chemiluminescence Efficiency for Sensitive Immunochromatographic Assay. Small, 2025, 21(34), 2503909. 3. Mingyue Ding# , Leina Dou#, Tong Bu, Zizhe Li, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Zhanhui Wang, Xiya Zhang#, Nanometal Surface Energy Transfer-based Lateral Flow Immunoassay for T2 Toxin Detection. Biosensors and Bioelectronics, 2025, 267(1), 116779. 4. Xiya Zhang^#, Qianqian Cui^#, Mingyue Ding, Yexuan Mao, Xianqing Huang, Lianjun Song, Tong Bu^, Fortified Donor−Acceptor Spectral Overlap Facilitated Fluorescence Quenching Efficiency for Developing Sensitive Nanometal Surface Energy Transfer-Based Immunochromatographic Test Strips, Analytical Chemistry, 2025, 97: 5209-5216. 5. Jinkui Wang# , Tong Bu#, Qianqian Cui, Zizhe Li, Qing Xu, Zhixian Jiang, Yexuan Mao, Xianqing Huang, Lianjun Song, Dapeng Peng, Xiya Zhang* A broad-spectrum antibody-based lateral flow immunoassay for detection of carbofuran and 3-hydroxy-carbofuran. Food Chemistry, 2025, 465:142062. 6. Mengtian Chen, Mengdi Yuan, Tong Bu, Yanmei Shi, Yang Wang, Xianqing Huang, Lianjun Song, Pingan Zhang, Xiya Zhang, Yexuan Mao. The mechanism of weakening fat-induced matrix interference by deep eutectic solvents promoting fat phase transfer: A case of aflatoxin B1 detection by lateral flow immunoassay in 26 food matrices. Food Chemistry, 2025, 493(2), 145886. 7. Zizhe Li#, Qianqian Cui#, Qingyue Li, Changwei Luo, Mengtian Chen, Beibei Feng, Huan Li, Tong Bu, Yexuan Mao, Meng Dang, Xianqing Huang, Lianjun Song, Dapeng Peng, Xiya Zhang. Preparation of ultra-sensitive anti-carbendazim antibodies based on new haptens and their application in lateral flow immunoassay. Sensors and Actuators B: Chemical, 2024, 135751. 8. Lianjun Song^#, Youyi Wang^#, Qingyue Li, Jinkui Wang, Tian Gao, Zhaohuan An, Qinfang Liu, Yexuan Mao, Tong Bu, Xianqing Huang, Yan Ma, Zhanhui Wang, Xiya Zhang. Production of monoclonal antibody against tylosin and tilmicosin with homogeneous crossreactivity and its application in lateral fow immunoassay. Microchimica Acta, 2024, 191(42). 9. Yawei Sun, Xiangjie Deng, Changwei Luo, Wentao Ma, Wanjing Liu, Jinkui Wang, Qingyue Li, Tong Bu,Xiya Zhang. Timeresolved fuorescence microspheresantibodypenicillinbinding protein assisted construction of immunochromatographic assay for sensitive detection of 22 βlactams in milk. Microchimica Acta, 2024, 191(50). 10. Xiya Zhang^#, Yuchen Bai^#, Qianqian Tang, Minggang Liu, Li Nan, Kai Wen, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Zhanhui Wang, Development of epitopephore-based rational hapten design strategy: A combination of theoretical evidence and experimental validation. Journal of Hazardous Material, 2023(445),130615. 11. Zizhe Li^#, Jinkui Wang^#, Youyi Wang, Qingyue Li, Xiaoyang Chen, Yu Wang, Haining Tian, Yexuan Mao, Lianjun Song, Xianqing Huang, Zhanhui Wang, Xiya Zhang, Development of a lateral flow immunoassay based on a highly specific monoclonal antibody to detect 4- methylaminoantipyrine. Journal of Agricultural and Food Chemistry, 2023. 71:10841-10849 12. Xiya Zhang^#, Zizhe Li^#, Yexuan Mao, Meng Dang, Xianqing Huang, Zhanhui Wang, Huijuan Yang, Yuchen Bai, Huahai Zhang* href="https://www.researchgate.net/publication/353113888_Production_of_highly_sensitive_monoclonal_antibody_and_development_of_lateral_flow_assays_for_phallotoxin_detection_in_urine" Production of high-affinity monoclonal antibody and development of immunoassay for 3-methyl-quinoxaline-2-carboxylic acid detection in swine muscle and liver. Food Chemistry, 2023 (407), 135175. 13. Yexuan Mao^#, Yichao Fan^#, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang*, A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. Electrochimica Acta, 461 (2023) , 142669. 14. Qiuyan Zhao,‡ Mingyue Ding,‡ Dangshuai Pei, Xiuhua Qi, Yexuan Mao, Xianqing Huang, Lianjun Song, Jingnan Zuo, Huijuan Yang and Xiya ZhangDevelopment of a monoclonal antibody-based lateral flow immunoassay for the detection of benzoic acid in liquid food. Analytical Methods, 2023,15, 6229-6238 15. Meng Dang^#, Zizhe Li^#, Yexuan Mao, Xianqing Huang, Lianjun Song, Wenfeng Li, Ruxiang Ma, Yang Liu, Liye Wang, Xuezhi Yu, Huijuan Yang, Xiya Zhang, A highly sensitive lateral fow immunoassay based on a groupspecifc monoclonal antibody and amorphous carbon nanoparticles for detection of sulfonamides in milk. Microchimica Acta,** 190 (2023):186. 授权专利 1. 张西亚; 李子哲; 毛烨炫; 宋莲军; 黄现青; 补彤; 王金奎; 李庆越. 一种杂交瘤细胞株及其分泌的安乃近残留标示物4-甲氨基安替比林单克隆抗体和应用。国家发明专利，专利申请号：CN202310247732X, 授权日期：2026-01-08。
教学科研获奖、指导学生参加竞赛获奖等情况	1.2025年获得河南省青年五四奖。 2.2025年获得河南省教育厅学术技术带头人。 3.2025年指导研究生获得河南农业大学硕士生优秀毕业论文。 4.2021年指导本科生获得河南农业大学优秀本科毕业论文。 5.指导学生获得2021年河南省“互联网+”大学生创新创业大赛二等奖。 6.2020年指导2017级食安2班获得“河南省先进班集体”和“河南省文明班集体”。
学术和社会兼职	药食质量安全数字化检测分会理事
国内外进修、访问情况	无
其他	经常参加食品安全检测相关研究的国内及国际会议。

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